The son of Nho Thi Nguyen and Ui Van Nguyen, Father Nguyen was born on August 7, 1964 in Vietnam. He grew up in a large family of 14 children and was 11 years-old when his family fled Vietnam and immigrated to the United States. They settled in Biloxi, Mississippi, where Father Nguyen became involved in the Vietnamese Eucharistic Youth Movement (VEYM) in grade school.